Human ANTXR1 Protein (Fc tag) – PKSH030646

Recombinant Human ANTXR1 Protein (Fc tag)

ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3′ kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key proteins. ANTXR1 interacts with extracellular matrix proteins and with the actin cytoskeleton. It functions in cell attachment and migration. ANTXR1 also mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. It plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

Synonym(s) : ANTXR1 ,ATR , TEM8

Species(s) : Human

Protein Expression Host : Human Cells

Protein Construction : A DNA sequence encoding the human ANTXR1 (Q9H6X2-4) (Met1-Ser321) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Predicted N-terminal amino acid : Glu 33

Molecular weight/mass : The recombinant human ANTXR1 /Fc is a disulfide-linked homodimer. The reduced monomer comprises 530 amino acids and has a predicted molecular mass of 59.4 kDa. The apparent molecular mass of the protein is approximately 69 kDa in SDS-PAGE under reducing conditions.

Protein Construction : A DNA sequence encoding the human ANTXR1 (Q9H6X2-4) (Met1-Ser321) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Formulation : Lyophilized from sterile PBS, pH 7.4

Purity : > 92 % as determined by SDS-PAGE

Endotoxin level : < 1.0 EU per μg of the protein as determined by the LAL method

Stability : Samples are stable for up to twelve months from date of receipt at -70°C

Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Reconstitution : Please refer to the printed manual for detailed information.

Manual & Datasheet