Human PTP1B / PTPN1 Protein (His Tag) – PKSH030416

Recombinant Human PTP1B / PTPN1 Protein (His Tag)

PTP1B, also known as PTPN1, belongs to the protein-tyrosine phosphatase (PTP) family. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTP1B contains 1 tyrosine-protein phosphatase domain and is expressed in many tissues. PTP1B is localized to the cytoplasmic face of the endoplasmic reticulum. PTP1B was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of PTP1B in cell growth control, and cell response to IFN stimulation.

Synonym(s) : PTP1B , PTPN1

Species(s) : Human

Protein Expression Host : E. coli

Protein Construction : A DNA sequence encoding the human PTPN1 (NP_002818.1) (Glu 2-Asn 321) was expressed, with a polyhistide tag at the N-terminus.

Predicted N-terminal amino acid : Met

Molecular weight/mass : The recombinant human PTPN1consisting of 327 amino acids and has a calculated molecular mass of 38 kDa.

Protein Construction : A DNA sequence encoding the human PTPN1 (NP_002818.1) (Glu 2-Asn 321) was expressed, with a polyhistide tag at the N-terminus.

Formulation : Supplied as sterile 10 mM Hepes, 150 mM NaCl, 1 mM DTT, pH 7.5

Purity : > 95 % as determined by SDS-PAGE

Endotoxin level :

Stability : Samples are stable for up to twelve months from date of receipt at -70°C

Shipping conditions : Liquid. It is shipped out with blue ice.

Reconstitution : Please refer to the printed manual for detailed information.

Manual & Datasheet