Rat MSR1 / SCARA1 Protein (His tag) – PKSR030203

Recombinant Rat MSR1 / SCARA1 Protein (His tag)

Macrophage scavenger receptor types I and II, also known as Macrophage acetylated LDL receptor I and II, Scavenger receptor class A member 1, CD204, MSR1 and SCARA1, is a single-pass type I I membrane protein which contains one collagen-like domain and one SRCR domain. Macrophages are distributed in all peripheral tissues and play a critical role in the first line of the innate immune defenses against bacterial infection by phagocytosis of bacterial pathogens through the macrophage scavenger receptor 1 (MSR1). MSR1 / SCARA1 is one of the membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL). MSR1 / SCARA1 is also involved in chronic inflammation which is a risk factor for prostate cancer. MSR1 1 gene was identified as a candidate susceptibility gene for hereditary prostate cancer and as a risk factor for sporadic prostate cancer.

Synonym(s) : MSR1

Species(s) : Rat

Protein Expression Host : Human Cells

Protein Construction : A DNA sequence encoding the rat MSR1 (NP_001178868.1) (Trp79-Ser454) was expressed with a polyhistidine tag at the N-terminus.

Predicted N-terminal amino acid : His

Molecular weight/mass : The recombinant rat MSR1 comprises 396 amino acids and has a predicted molecular mass of 43.1 kDa. The apparent molecular mass of the protein is approximately 51-60 kDa in SDS-PAGE under reducing conditions.

Protein Construction : A DNA sequence encoding the rat MSR1 (NP_001178868.1) (Trp79-Ser454) was expressed with a polyhistidine tag at the N-terminus.

Formulation : Lyophilized from sterile PBS, pH 7.4

Purity : > 95 % as determined by SDS-PAGE

Endotoxin level : < 1.0 EU per μg of the protein as determined by the LAL method

Stability : Samples are stable for up to twelve months from date of receipt at -70°C

Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Reconstitution : Please refer to the printed manual for detailed information.

Manual & Datasheet