Human BCL6 / B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx tag) – PKSH030910

Recombinant Human BCL6 / B-cell CLL lymphoma 6 Protein (aa 1-150, His & Trx tag)

The protein encoded by this gene is an evolutionarily conserved 95-kDa protein containing six C-terminal zinc-finger motifs and an N-terminal POZ domain. It has been reported that BCL-6 is present in DNA-binding complexes in nuclear extracts from various B-cell lines. There are many relationships between non-Hodgkin’s lymphoma, diffuse large cell lymphoma and BCL6’s translocations. BCL6 can repress transcription from promoters linked to its DNA target sequence and this activity is dependent upon specific DNA-binding and the presence of an intact N-terminal half of the protein.

Synonym(s) : BCL5 , BCL6A , LAZ3 , ZBTB27 , ZNF51

Species(s) : Human

Protein Expression Host : E. coli

Protein Construction : A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus.

Predicted N-terminal amino acid : Met

Molecular weight/mass : The recombinant human BCL6/Trx fusion protein consisting of 309 amino acids and has a calculated molecular mass of 34.2 kDa. It migrates as an approximately 33 kDa band in SDS-PAGE under reducing conditions.

Protein Construction : A DNA sequence encoding the human BCL6 (P41182) N-terminal fragment (Met 1-Met 150) was fused with a Trx and a polyhistidine tag at the N-terminus.

Formulation : Lyophilized from sterile 20mM Tris, 10% glycerolcerol, pH 8.0

Purity : > 92 % as determined by SDS-PAGE

Endotoxin level :

Stability : Samples are stable for up to twelve months from date of receipt at -70°C

Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Reconstitution : Please refer to the printed manual for detailed information.

Manual & Datasheet