Human VEGFR1 / FLT-1 Protein (His tag) – PKSH031841

Recombinant Human VEGFR1 / FLT-1 Protein (His tag)

Vascular endothelial growth factor receptor 1, also known as VEGFR-1, Fms-like tyrosine kinase 1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, Vascular permeability factor receptor and FLT1, is a single-pass type I membrane protein and secreted protein which belongs to the protein kinase superfamily, Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 / FLT1 contains seven Ig-like C2-type (immunoglobulin-like) domains and one protein kinase domain. VEGFR-1 / FLT1 is expressed mostly in normal lung, but also in placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. VEGFR-1 / FLT1 is not expressed in tumor cell lines. VEGFR-1 / FLT1 is an essential receptor tyrosine kinase that regulates mammalian vascular development and embryogenesis. EGF-induced angiogenesis requires inverse regulation of VEGFR-1 and VEGFR-2 in tumor-associated endothelial cells. VEGFR-1 / FLT1 is a receptor for VEGF, VEGFB and PGF. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability.

Synonym(s) : FLT , FRT , VEGFR1

Species(s) : Human

Protein Expression Host : Human Cells

Protein Construction : A DNA sequence encoding the human FLT1 (NP_002010.2) (Met1-Ile328) was expressed with a polyhistidine tag at the C-terminus.

Predicted N-terminal amino acid : Ser 27

Molecular weight/mass : The recombinant human FLT1 consists 313 amino acids and predicts a molecular mass of 35.6 kDa.

Protein Construction : A DNA sequence encoding the human FLT1 (NP_002010.2) (Met1-Ile328) was expressed with a polyhistidine tag at the C-terminus.

Formulation  : Lyophilized from sterile PBS, pH 7.4

Purity : > 95 % as determined by SDS-PAGE.

Endotoxin level : <1.0 EU per μg protein as determined by the LAL method.

Stability : Samples are stable for up to twelve months from date of receipt at -70°C

Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Reconstitution : Please refer to the printed manual for detailed information.

Manual & Datasheet