Human ALDH1A3 / RALDH3 Protein (His tag) – PKSH031051

Recombinant Human ALDH1A3 / RALDH3 Protein (His tag)

Aldehyde dehydrogenase 1 family, member A3 (ALDH1A3), also known as Retinaldehyde dehydrogenase 3 (RALDH3), which belongs to the aldehyde dehydrogenase family. ALDH1A3 is a novel Cancer stem cell (CSC) marker with potential clinical prognostic applicability, and demonstrates a clear correlation between CSC prevalence and the development of metastatic breast cancer. The retinoic acid (RA) biosynthesis enzyme aldehyde dehydrogenase 1A3 (ALDH1A3) is a putative androgen-responsive gene in human prostate cancer epithelial (LNCaP) cells. The RA biosynthesis enzyme ALDH1A3 is androgen responsive and (ii) DHT up-regulation of ALDH1A3 can increase the oxidation of retinal to RA and indirectly affect RA bioactivity and metabolism.

Synonym(s) : ALDH1A6 , ALDH6 , RALDH3

Species(s) : Human

Protein Expression Host : E. coli

Protein Construction : A DNA sequence encoding the human ALDH1A3 (NP_000684.2) (Ala 2-Pro 512) was expressed, with a polyhistide tag at the N-terminus.

Predicted N-terminal amino acid : Met

Molecular weight/mass : The recombinant human ALDH1A3 consisting of 518 amino acids and migrates as an approximately 57 kDa band in SDS-PAGE under reducing conditions as predicted.

Protein Construction : A DNA sequence encoding the human ALDH1A3 (NP_000684.2) (Ala 2-Pro 512) was expressed, with a polyhistide tag at the N-terminus.

Formulation : Lyophilized from sterile PBS, 0.5M NaCl, pH 8.0

Purity : > 96 % as determined by SDS-PAGE

Endotoxin level :

Stability : Samples are stable for up to twelve months from date of receipt at -70°C

Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Reconstitution : Please refer to the printed manual for detailed information.

Manual & Datasheet