Recombinant Rat EphA7 / Eph Receptor A7 Protein (Fc Tag)
Ephrin type-A receptor 7, also known as EphA7, belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family which 16 known receptors (14 found in mammals) are involved: EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHA9, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB5, EPHB6. The Eph family of receptor tyrosine kinases (comprising EphA and EphB receptors) has been implicated in synapse formation and the regulation of synaptic function and plasticity6. Eph receptor-mediated signaling, which is triggered by ephrins7, probably modifies the properties of synapses during synaptic activation and remodeling. Ephrin receptors are components of cell signalling pathways involved in animal growth and development, forming the largest sub-family of receptor tyrosine kinases (RTKs). Ligand-mediated activation of Ephs induce various important downstream effects and Eph receptors have been studied for their potential roles in the development of cancer. Down-regulation of EphA7 secondary to hypermethylation has been reported in colorectal cancer. The expression of EphA7 was reduced in all tested gastric cancer cell lines; however, there is marked variability in expression among gastric carcinoma specimens. EphA7 may have roles in the pathogenesis and development of gastric carcinomas.
Synonym(s) : Ehk-3 , Ehk3
Species(s) : Rat
Protein Expression Host : Human Cells
Protein Construction : A DNA sequence encoding the rat Epha7 (NP_599158.1) (Met1-Ser539) was expressed with the Fc region of human IgG1 at the C-terminus.
Predicted N-terminal amino acid : Gln 28
Molecular weight/mass : The recombinant rat Epha7 consists 523 amino acids and predicts a molecular mass of 58.9 kDa.
Protein Construction : A DNA sequence encoding the rat Epha7 (NP_599158.1) (Met1-Ser539) was expressed with the Fc region of human IgG1 at the C-terminus.
Formulation : Lyophilized from sterile PBS, pH 7.4
Purity : > 90 % as determined by SDS-PAGE.
Endotoxin level : < 1.0 EU per μg protein as determined by the LAL method.
Stability : Samples are stable for up to twelve months from date of receipt at -70°C
Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Reconstitution : Please refer to the printed manual for detailed information.
Additional information
Format | 200 ug, 50 ug |
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Species | Rat |
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