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Rat Carboxypeptidase B2 / CPB2 Protein (His Tag) – PKSR030144

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Recombinant Rat Carboxypeptidase B2 / CPB2 Protein (His Tag)

Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). CPB2 is activated by thrombin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen. When it is activated by proteolysis at residue Arg92 by the thrombin / thrombomodulin complex. CPB2 cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. CPB2 exhibits carboxypeptidase activity and activated CPB2 reduces fibrinolysis by removing the fibrin C-terminal residues that are important for the binding and activation of plasminogen.


Synonym(s) : CPB2


Species(s) : Rat


Protein Expression Host : Human Cells


Protein Construction : A DNA sequence encoding the rat Cpb2 (NP_446069.1) (Met1-Ser422) was expressed with a polyhistidine tag at the C-terminus.


Predicted N-terminal amino acid : Phe 22


Molecular weight/mass : The recombinant rat Cpb2 consists of 412 amino acids and predicts a molecular mass of 48 kDa.


Protein Construction : A DNA sequence encoding the rat Cpb2 (NP_446069.1) (Met1-Ser422) was expressed with a polyhistidine tag at the C-terminus.


Formulation : Lyophilized from sterile PBS, pH 7.4


Purity : > 95 % as determined by SDS-PAGE.


Endotoxin level : < 1.0 EU per μg protein as determined by the LAL method.


Stability : Samples are stable for up to twelve months from date of receipt at -70°C


Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.


Reconstitution : Please refer to the printed manual for detailed information.


Manual & Datasheet


Additional information

Format

100 ug, 20 ug

Species

Rat

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