Phospho-Catenin-β (Ser37) Polyclonal Antibody
Background information : Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.
Research area(s) : Stem cells | Cancer | Epigenetics
Validated applications : WB | IHC | IF | ELISA
Suggested dilutions : WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:100, ELISA 1:5000-1:20000
Calculated MW : 85 kDa
Observed MW (if applicable) :
Alternate names: CTNNB1, CTNNB, OK/SW-cl.35, Catenin beta-1, Beta-catenin
Available sizes : 20 ul, 60 ul, 120 ul, 200 ul
Conjugation : none
Clonality : Rabbit polyclonal
Isotype : IgG
Clone number :
Reactivity : Human | Mouse | Rat
Immunogen : Synthesized peptide derived from human Catenin-β around the phosphorylation site of Ser37
Swissprot ID : P35222
Gene ID / Accession : 1499 /
Purification method : Affinity purification
Supplied in : PBS with 0.02% sodium azide,50% glycerol and 0.5% BSA
Concentration : 1 mg/ml
Storage : Store at -20°C.Avoid freeze / thaw cycles.
Other informations :
Link to Elabscience product page
Previous Catalog Number: ENP0047
Additional information
Validated Applications | IF, IHC, ELISA, WB |
---|---|
Reactivity | Human, Mouse, Rat |
Research Area(s) | |
Product Name | Phospho-Catenin-β (Ser37) Polyclonal Antibody |
Supplier | |
Isotype | IgG |
Host | Rabbit |
Clonality | Polyclonal |
Format | 20 ul, 60 ul, 120 ul, 200 ul |
Conjugation | None |
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