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Phospho-Catenin-β (Ser37) Polyclonal Antibody – E-AB-20828

  • Clonality : Rabbit Polyclonal
  • Applications : WB | IHC | IF | ELISA
  • Reactivity : Human | Mouse | Rat

$185.00$653.00 CAD

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Phospho-Catenin-β (Ser37) Polyclonal Antibody


Background information : Key dowstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes.Involved in the regulation of cell adhesion. The majority of beta-catenin is localized to the cell membrane and is part of E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.


Research area(s) : Stem cells | Cancer | Epigenetics


Validated applications : WB | IHC | IF | ELISA


Suggested dilutions : WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:100, ELISA 1:5000-1:20000


Calculated MW : 85 kDa


Observed MW (if applicable) :


Alternate names: CTNNB1, CTNNB, OK/SW-cl.35, Catenin beta-1, Beta-catenin


Available sizes : 20 ul, 60 ul, 120 ul, 200 ul


Conjugation : none


Clonality : Rabbit polyclonal


Isotype : IgG


Clone number :


Reactivity : Human | Mouse | Rat


Immunogen : Synthesized peptide derived from human Catenin-β around the phosphorylation site of Ser37


Swissprot ID : P35222


Gene ID / Accession : 1499 /


Purification method : Affinity purification


Supplied in : PBS with 0.02% sodium azide,50% glycerol and 0.5% BSA


Concentration : 1 mg/ml


Storage : Store at -20°C.Avoid freeze / thaw cycles.


Other informations :

Link to Elabscience product page

Previous Catalog Number: ENP0047


Manual & Datasheet


Additional information

Validated Applications

IF, IHC, ELISA, WB

Reactivity

Human, Mouse, Rat

Research Area(s)

, ,

Product Name

Phospho-Catenin-β (Ser37) Polyclonal Antibody

Supplier

Isotype

IgG

Host

Rabbit

Clonality

Polyclonal

Format

20 ul, 60 ul, 120 ul, 200 ul

Conjugation

None

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