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Peripherin Antibody – RPCA-Peri

  • Clonality : Rabbit Polyclonal
  • Applications : WB | IF/ICC | IHC
  • Reactivity : Human | Horse | Cow | Pig | Chicken | Rat | Mouse

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Encor Rabbit Polyclonal to Peripherin, PRPH 

Peripherin is a ~57 kDa intermediate filament subunit found initially in sensory neurons of the peripheral nervous systems, which gives the protein its name (1). Subsequently, peripherin was found in some sensory and other neurons of the central nervous system and also in rat pheochromacytoma PC12 cells (2,3). Peripherin is also expressed in certain neuroendocrine tumors and in the insulin producing cells of the pancreas. Peripherin belongs to the Class III family of intermediate filament subunits which also includes vimentin, glial fibrillary acidic protein (GFAP) and desmin.
Antibodies to peripherin can be used in identifying, classifying, and studying neurons throughout the nervous system. Peripherin is also a good diagnostic marker for ballooned axons seen in Lou Gehrig’s disease (Amyotrophic lateral sclerosis) and some neuronally derived tumors. Autoantibodies to peripherin are frequently seen in the sera of patients with diabetes. Peripherin is not related to peripherin/RDS, (PRPH2) a protein of the photoreceptor outer membrane mutations of which are causative of certain forms of slow retinal degeneration.

The characterization of an antibody produced in the same way as RPCA-Peri has been published (4). The HGNC name for this protein is PRPH.


HGNC name(s) : PRPH


Host : Rabbit


Clonality : Polyclonal


ID : EnCor Biotechnology Peripherin Peri


Reactivity : Human | Horse | Cow | Pig | Chicken | Rat | Mouse


Isotype : IgG


Conjugation : none


Immunogen : Recombinant full length rat


Mass of detected protein : 57 kDa


Uniprot ID : P23942


KGNC name : PRPH


RRID # : AB_2572375


Purification : Serum


Storage : Shipped on ice. Store at 4°C. For long term storage, leave frozen at -20°C. Avoid freeze / thaw cycles.


Validated applications : WB | IF/ICC | IHC


Suggested Dilutions: 

WB: 1:1000-1:2 000. ICC/IF and IHC: 1:2 000.


Datasheet


Link to on EnCor’s website 


References :

1. Portier MM, de Néchaud B, Gros F. Peripherin, a new member of the intermediate filament protein family. Dev Neurosci. 6:335-44 (1984)

2. Troy CM, Brown K, Greene LA, Shelanski ML. Ontogeny of the neuronal intermediate filament protein, peripherin, in the mouse embryo. Neuroscience 36:217-37 (1990).

3. Aletta JM, Angeletti R, Liem RK, Purcell C, Shelanski ML, Greene LA. Relationship between the nerve growth factor-regulated clone 73 gene product and the 58-kilodalton neuronal intermediate filament protein (peripherin). J. Neurochem 51:1317-20 (1988).

4. Errante LD, Wiche G and Shaw G. Distribution of plectin, an intermediate filament-associated protein, in the adult rat central nervous system J. Neurosci. Res. 37:515-528 (1994).


Additional information

Format

50 ul, 100 ul, 500 ul

Supplier
Host
Clonality
Reactivity
Validated Applications
Conjugation
Isotype

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299.00$1,597.00$ CAD

Clear

Cashback Reward : Earn up to 159$!