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Mouse SynCam / CADM1 / TSLC1 / IGSF4 Protein (His Tag) – PKSM040627

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Recombinant Mouse SynCam / CADM1 / TSLC1 / IGSF4 Protein (His Tag)

Members of the immunoglobulin superfamily often play key roles in intercellular adhesion. IGSF4 is a novel immunoglobulin (Ig)-like intercellular adhesion molecule. Three Ig-like domains are included in the extracellular domain of IGSF4 and mediate homophilic or heterophilic interactions independently of Ca2+. The cytoplasmic domain of IGSF4 contains the binding motifs that connect to actin fibers. Since IGSF4 has been characterized by several independent research groups, this molecule is called by three names, TSLC1, SgIGSF and SynCAM. IGSF4 was first characterized as a tumor suppressor of non-small cell lung cancer and termed TSLC1. It is a single-pass type I membrane protein which belongs to the nectin family, which may be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons. In addition, CADM1 may play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. In neuroblastoma, loss of CADM1 expression has recently been found in disseminated tumours with adverse outcome, prompting us to investigate its role in neuroblastoma tumour progression. The downregulation of CADM1 tumour suppressor gene expression is a critical event in neuroblastoma pathogenesis resulting in tumour progression.


Synonym(s) : Igsf4 , Necl2 , Ra175 , Syncam , SynCam1 , Tslc1


Species(s) : Mouse


Protein Expression Host : Human Cells


Protein Construction : A DNA sequence encoding the mouse Cadm1 (NP_061240.3) (Met1-His377) was expressed with a polyhistidine tag at the C-terminus.


Predicted N-terminal amino acid : Gln 48


Molecular weight/mass : The recombinant mouse Cadm1 consists 341 amino acids and predicts a molecular mass of 38.5 kDa.


Protein Construction : A DNA sequence encoding the mouse Cadm1 (NP_061240.3) (Met1-His377) was expressed with a polyhistidine tag at the C-terminus.


Formulation : Lyophilized from sterile PBS, pH 7.4


Purity : > 95 % as determined by SDS-PAGE.


Endotoxin level : < 1.0 EU per μg protein as determined by the LAL method.


Stability : Samples are stable for up to twelve months from date of receipt at -70°C


Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.


Reconstitution : Please refer to the printed manual for detailed information.


Manual & Datasheet


Additional information

Format

200 ug, 50 ug

Species

Mouse

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