Mouse CXADR / CAR Protein (ECD, Fc & His Tag) – PKSM040316

Recombinant Mouse CXADR / CAR Protein (ECD, Fc & His Tag)

CXADR (coxsackie virus and adenovirus receptor), also known as CAR, is a type I transmembrane glycoprotein belonging to the CTX family of the Ig superfamily, and is essential for normal cardiac development in the mouse. Proposed as a homophilic cell adhesion molecule, CXADR is a component of the epithelial apical junction complex that is essential for the tight junction integrity, and probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN). Mature mouse CXADR structrually comprises a 218 aa extracellular domain (ECD) with a V-type (D1) and a C2-type (D2) Ig-like domain, a 21 aa transmembrane segment and a 107 aa intracellular domain, among which,D1 is thought to be responsible for homodimer formation in trans within tight junctions. The ECD of mouse CXADR shares 97%, 90% sequence identity with the corresponding regions of rat, human CXADR.

Synonym(s) : Car

Species(s) : Mouse

Protein Expression Host : Human Cells

Protein Construction : A DNA sequence encoding the mouse Cxadr (NP_001020363.1) (Met1-Gly237) was expressed with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus (Fc-his).

Predicted N-terminal amino acid : Leu 20

Molecular weight/mass : The recombinant mouse Cxadr consists of 465 amino acids and predicts a molecular mass of 52 kDa.

Protein Construction : A DNA sequence encoding the mouse Cxadr (NP_001020363.1) (Met1-Gly237) was expressed with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus (Fc-his).

Formulation : Lyophilized from sterile PBS, pH 7.4

Purity : > 95 % as determined by SDS-PAGE.

Endotoxin level : < 1.0 EU per μg protein as determined by the LAL method.

Stability : Samples are stable for up to twelve months from date of receipt at -70°C

Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Reconstitution : Please refer to the printed manual for detailed information.

Manual & Datasheet