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Human TGFB1 (LAP) / TGF-beta 1 Protein (His Tag) – PKSH030441

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Recombinant Human TGFB1 (LAP) / TGF-beta 1 Protein (His Tag)

TGF-beta 1 is a member of the transforming growth factor beta (TGF-beta) family. The transforming growth factor-beta family of polypeptides are involved in the regulation of cellular processes, including cell division, differentiation, motility, adhesion and death. TGF-beta 1 positively and negatively regulates many other growth factors. It inhibits the secretion and activity of many other cytokines including interferon-γ, tumor necrosis factor-alpha and various interleukins. It can also decrease the expression levels of cytokine receptors. Meanwhile, TGF-beta 1 also increases the expression of certain cytokines in T cells and promotes their proliferation, particularly if the cells are immature. TGF-beta 1 also inhibits proliferation and stimulates apoptosis of B cells, and plays a role in controlling the expression of antibody, transferrin and MHC class II proteins on immature and mature B cells. As for myeloid cells, TGF-beta 1can inhibit their proliferation and prevent their production of reactive oxygen and nitrogen intermediates. However, as with other cell types, TGF-beta 1 also has the opposite effect on cells of myeloid origin. TGF-beta 1 is a multifunctional protein that controls proliferation, differentiation and other functions in many cell types. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Once cells lose their sensitivity to TGF-beta1-mediated growth inhibition, autocrine TGF-beta signaling can promote tumorigenesis. Elevated levels of TGF-beta1 are often observed in advanced carcinomas, and have been correlated with increased tumor invasiveness and disease progression.


Synonym(s) : TGFB1


Species(s) : Human


Protein Expression Host : Human Cells


Protein Construction : A DNA sequence encoding the Latency-associated peptide(LAP)of human TGFB1(Met1-Arg278) was expressed with a polyhistidine tag at the C-terminus.


Predicted N-terminal amino acid : Leu 30


Molecular weight/mass : The recombinant Latency-associated peptide(LAP)of human TGFB1 consists of 260 amino acids and predicts a molecular mass of 29.9 kDa.


Protein Construction : A DNA sequence encoding the Latency-associated peptide(LAP)of human TGFB1(Met1-Arg278) was expressed with a polyhistidine tag at the C-terminus.


Formulation : Lyophilized from sterile PBS, pH 7.4


Purity : > 95 % as determined by SDS-PAGE.


Endotoxin level : < 1.0 EU per μg protein as determined by the LAL method.


Stability : Samples are stable for up to twelve months from date of receipt at -70°C


Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.


Reconstitution : Please refer to the printed manual for detailed information.


Manual & Datasheet


Additional information

Format

100 ug, 20 ug

Species

Human

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