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Human NFASC / Neurofascin protein (Fc Tag) – PKSH030462

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Recombinant Human NFASC / Neurofascin protein (Fc Tag)

NFASC, also known as neurofascin, belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. NFASC functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton.


Synonym(s) : KIAA0756


Species(s) : Human


Protein Expression Host : Human Cells


Protein Construction : A DNA sequence encoding the human NFASC (NP_001005388.2) (Met1-Gln939) was expressed with the Fc region of human IgG1 at the C-terminus.


Predicted N-terminal amino acid : Ile 25


Molecular weight/mass : The recombinant human NFASC consists 1156 amino acids and predicts a molecular mass of 130 kDa.


Protein Construction : A DNA sequence encoding the human NFASC (NP_001005388.2) (Met1-Gln939) was expressed with the Fc region of human IgG1 at the C-terminus.


Formulation  : Lyophilized from sterile PBS, pH 7.4


Purity : > 95 % as determined by SDS-PAGE.


Endotoxin level : <1.0 EU per μg protein as determined by the LAL method.


Stability : Samples are stable for up to twelve months from date of receipt at -70°C


Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.


Reconstitution : Please refer to the printed manual for detailed information.


Manual & Datasheet


Additional information

Format

200 ug, 50 ug

Species

Human

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