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Human LBP / Lipopolysaccharide binding Protein (His tag) – PKSH031548

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Recombinant Human LBP / Lipopolysaccharide binding Protein (His tag)

Lipopolysaccharide binding protein (LBP) is a glycoprotein that is synthesized principally by hepatocytes. LBP is a trace plasma protein that binds to the lipid A moiety of bacterial lipopolysaccharides (LPSs). LBP binds directly to the outer membrane of Gram-negative bacteria and to purified aggregates of extracted endotoxin, and catalyses the delivery of endotoxin to membrane (mCD14,GPI-Linked) and soluble (sCD14) forms of CD14, thereby markedly increasing host cell sensitivity to endotoxin. LBP efficiently catalyses the transfer of individual molecules of endotoxin to (s)CD14 only when LBP–endotoxin aggregates are formed in the presence of albumin. In the presence of EDTA, LBP binding promotes further disaggregation of endotoxin. LBP binding does not have such drastic effects under more physiological conditions, but may still induce more subtle topological rearrangements of endotoxin.


Synonym(s) : MGC22233 , LBP


Species(s) : Human


Protein Expression Host : Human Cells


Protein Construction : A DNA sequence encoding the human LBP (NP_004130.2) extracellular domain (Met 1-Val 481) was fused with the a polyhistidine tag at the C-terminus.


Predicted N-terminal amino acid : Ala 26


Molecular weight/mass : The recombinant human LBP consists of 467 amino acids and has a predicted molecular mass of 52.5 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhLBP is approximately 62 kDa due to glycosylation.


Protein Construction : A DNA sequence encoding the human LBP (NP_004130.2) extracellular domain (Met 1-Val 481) was fused with the a polyhistidine tag at the C-terminus.


Formulation : Lyophilized from sterile 20mM Tris, 100mM NaCl, 0.05mM EDTA, pH 8.0


Purity : > 95 % as determined by SDS-PAGE


Endotoxin level : < 1.0 EU per μg of the protein as determined by the LAL method


Stability : Samples are stable for up to twelve months from date of receipt at -70°C


Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.


Reconstitution : Please refer to the printed manual for detailed information.


Manual & Datasheet


Additional information

Format

20 ug, 50 ug

Species

Human

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