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Human LAG3 / CD223 / Lymphocyte activation gene 3 Protein (Fc Tag) – PKSH030460

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Recombinant Human LAG3 / CD223 / Lymphocyte activation gene 3 Protein (Fc Tag)

LAG3, also known as CD223 and Lymphocyte activation gene 3, belongs to immunoglobulin (Ig) superfamily. LAG3 contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. It is selectively expressed in activated T and NK cells. LAG3 has a negative regulatory function in T cells. It also acts as as a new marker of T cell induced B cell activation. As a soluble molecule, LAG3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.


Synonym(s) : FDC


Species(s) : Human


Protein Expression Host : Human Cells


Protein Construction : A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was expressed with the Fc region of human IgG1 at the C-terminus.


Predicted N-terminal amino acid : Val 29


Molecular weight/mass : The recombinant human LAG3 consists 660 amino acids and predicts a molecular mass of 72.3 kDa.


Protein Construction : A DNA sequence encoding the human LAG3 (NP_002277.4) (Met1-Leu450) was expressed with the Fc region of human IgG1 at the C-terminus.


Formulation : Lyophilized from sterile PBS, pH 7.4


Purity : > (3.0+91.0+3.1) % as determined by SDS-PAGE.


Endotoxin level : <1.0 EU per μg protein as determined by the LAL method.


Stability : Samples are stable for up to twelve months from date of receipt at -70°C


Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.


Reconstitution : Please refer to the printed manual for detailed information.


Manual & Datasheet


Additional information

Format

200 ug, 50 ug

Species

Human

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