Human DOPA Decarboxylase / DDC Protein (His tag) – PKSH030408
$1,546.00 – $2,499.00 CAD
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Recombinant Human DOPA Decarboxylase / DDC Protein (His tag)
Dopa Decarboxylase (DDC), also known as AADC and Aromatic-L-amino acid decarboxylase, is a 54 kDa member of the group II decarboxylase family of proteins.It is a vitamin B6-dependent homodimeric enzyme that catalyzes the decarboxylation of both L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan to dopamine and serotonin, respectively, which are major mammalian neurotransmitters and hormones belonging to catecholamines and indoleamines. Since L-DOPA is regularly used to treat the symptoms of Parkinson’s disease, the catalytic pathway is of particular research interest. Defects of DDC are associated with severe developmental delay, oculogyric crises (OGC), as well as autosomal recessive disorder AADC deficiency, an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency.
Synonym(s) : AADC , DDC
Species(s) : Human
Protein Expression Host : Baculovirus-Insect Cells
Protein Construction : A DNA sequence encoding the full length of human DDC (NP_000781.1) (Met 1-Glu 480) was expressed with a polyhistidine tag at the C-terminus.
Predicted N-terminal amino acid : Met
Molecular weight/mass : The recombinant human DDC consists of 490 amino acids and predicts a molecular mass of 55 kDa. It migrates as an approximately 48 kDa protein in SDS-PAGE under reducing conditions.
Protein Construction : A DNA sequence encoding the full length of human DDC (NP_000781.1) (Met 1-Glu 480) was expressed with a polyhistidine tag at the C-terminus.
Formulation : Supplied as sterile 50mM Tris, 100mM NaCl, pH 8, 10% glycerolcerol
Purity : > 90 % as determined by SDS-PAGE
Endotoxin level : < 1.0 EU per μg of the protein as determined by the LAL method
Stability : Samples are stable for up to twelve months from date of receipt at -70°C
Shipping conditions : Liquid. It is shipped out with blue ice.
Reconstitution : Please refer to the printed manual for detailed information.
Additional information
Format | 20 ug, 50 ug |
---|---|
Species | Human |
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