Select Page

Human Coagulation Factor XI / FXI / F11 Protein (His tag) – PKSH031696

1,371.00$2,062.00$ CAD

Clear

Cashback Reward : Earn up to 206$!


Recombinant Human Coagulation Factor XI / FXI / F11 Protein (His tag)

Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa and then is processed into a disulfide-bond linked homodimer. FXI is a homodimer, with each subunit containing four apple domains and a protease domain. The apple domains form a disk structure with binding sites for platelets, high molecular weight kininogen, and the substrate factor IX (FIX). FXI is converted to the active protease FXIa by cleavage of the Arg369-Ile370 bond on each subunit. After the activation reaction, Factor XIa is composed of two heavy and two light chains held together by three disulfide bonds. The heavy chains are derived from the amino termini of the zymogen and responsible for the binding of factor XI to high molecular weight kininogen and for the activation of factor IX, while the light chain contains the catalytic portion of the enzyme and is homologous to the trypsin family of serine proteases. FXI deficiency is a disorder characterized by a mild or no bleeding tendency. Severe FXI deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide.


Synonym(s) : FXI , MGC141891 , F11


Species(s) : Human


Protein Expression Host : Human Cells


Protein Construction : A DNA sequence encoding the human F11 (NP_000119.1) precursor (Met 1-Val 625) with a carboxy-terminal polyhistidine tag was expressed.


Predicted N-terminal amino acid : Glu 19


Molecular weight/mass : The secreted recombinant human F11 consists of 618 amino acids with the predicted molecular mass of 69.5 kDa. As a result of glycosylation, rhCTSS migrates as an approximately 75-80 kDa band in SDS-PAGE under reducing conditions.


Protein Construction : A DNA sequence encoding the human F11 (NP_000119.1) precursor (Met 1-Val 625) with a carboxy-terminal polyhistidine tag was expressed.


Formulation  : Lyophilized from sterile PBS, pH 7.4


Purity : > 85 % as determined by SDS-PAGE


Endotoxin level : < 1.0 EU per μg of the protein as determined by the LAL method


Stability : Samples are stable for up to twelve months from date of receipt at -70°C


Shipping conditions : In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.


Reconstitution : Please refer to the printed manual for detailed information.


Manual & Datasheet


Additional information

Format

20 ug, 50 ug

Species

Human

Ask a question about Human Coagulation Factor XI / FXI / F11 Protein (His tag) – PKSH031696

Product Reviews for Human Coagulation Factor XI / FXI / F11 Protein (His tag) – PKSH031696

Reviews

There are no reviews yet.

Be the first to review “Human Coagulation Factor XI / FXI / F11 Protein (His tag) – PKSH031696”

Your email address will not be published. Required fields are marked *

Related Products

More to Read

4th Anniversary Celebration

4th Anniversary Celebration

by Simon Roy | Sep 16th, 2019 | Latest News, Promotions | Promo code : civicbio4-50 1 per customer. Using this coupon will reduce Cashback Reward earning rate by 50%.  Until Nov, 30th, 2019 Double your Cashback Rewards with any product purchase! + Cashback x1.5...

PCR Purification Kit Comparison – DNA Clean Up

PCR Purification Kit Comparison – DNA Clean Up

Which is the Best Kit for DNA Clean Up? Our aim was to perform a PCR Purification Kit Comparison from different vendors. At Civic Bioscience, we distribute the Favorprep™ and EasyPure® product lines from FAVORGEN and TransBionovo respectively. First, the FavorPrep™...

The Truth about Antibodies used for Research

The Truth about Antibodies used for Research

The Problem with Antibodies used for Research Antibodies used for Research in academic, industrial and therapeutic fields are universal reagents in molecular biology assays. Without them, the entire field of medical research could collapse. However, there are many...

Detection Limit of Taq DNA Polymerase

Detection Limit of Taq DNA Polymerase

What's the Detection Limit of Taq ? How many DNA copies from gDNA? There are MANY Taq DNA Polymerases out there on the market. Some are driven by strong marketing and others by strong performance. Our aim was to verify the Detection Limit of Taq DNA Polymerases in PCR...

The 2019-2020 Price List is now available

A huge THANK YOU for your support! MERCI encore INFINIMENT de supporter notre jeune compagnie!   by Simon Roy | September 16th, 2019 | Company Posts, Latest NewsPrices for services vary case by case. 4rth anniversary promotions are coming soon! Let's CELEBRATE...