Galectin 3 Antibody – MCA-5C21

Encor Mouse Monoclonal to Galectin-3

This protein has several names including macrophage galactose-specific lectin or MAC2, galactoside-binding protein or GALBP, or Galectin 3 or Gal 3. It is a highly conserved molecule about 30 kDa in size.
Galectin 3 is a member of a multigene family of 15 vertebrate lectins all of which share one or in some cases two “carbohydrate recognition domains” (CRD) which bind to β-galactoside, a sugar moiety found on many cell surface proteins (1). Gal-3 is unusual in that it also includes, at the N terminus, multiple proline, tyrosine and glycine rich repeats which allows this molecule to oligomerize, so allowing high avidity binding to β-galactoside.

Gal-3 is a multifunctional protein which is expressed both on the cell surface, cytoplasm and nucleus, and which appears to function both in specific carbohydrate binding and in the regulation of mRNA splicing (1,2). Much evidence suggests that Gal-3 has an important role in the regulation of inflammatory responses and fibrogenesis (3). The HGNC name for this protein is LGALS3.

---

HGNC name(s) : LGALS3

---

Host : Mouse

---

Clonality : Monoclonal

---

ID : EnCor Biotechnology Galectin 3 5C21

---

Reactivity : Human | Horse | Cow | Pig | Rat | Mouse

---

Isotype : IgG1

---

Conjugation : none

---

Immunogen : Recombinant full length human

---

Mass of detected protein : 30 kDa

---

Uniprot ID : P17931

---

KGNC name : LGALS3

---

RRID # : AB_2572283

---

Purification : Affinity purified at 1 mg/mL

---

Storage : Shipped on ice. Store at 4°C. For long term storage, leave frozen at -20°C. Avoid freeze / thaw cycles.

---

Validated applications : WB | IF/ICC | IHC

---

Suggested Dilutions:

WB:1:5 000. ICC/IF and IHC: 1:2 000 .

---

Datasheet

---

Link to on EnCor’s website

---

References :

1. Haudek, K. C., Patterson, R. J., Wang, J. L. SR proteins and galectins: what’s in a name? Glycobiology 20:1199-1207 (2011).

2. Haudek, K. C., Spronk, K. J., Voss, P. G., Patterson, R. J., Wang, J. L., Arnoys, E. J. Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim. Biophys. Acta. 1800:181-189 (2011).

3. Henderson, N. C., Sethi, T. The regulation of inflammation by galectin-3. Immunological Reviews 230:160-171 (2009).

---