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Acetyl-Ref-1 (Lys6) Polyclonal Antibody – E-AB-20213

  • Clonality : Rabbit Polyclonal
  • Applications : WB | ELISA
  • Reactivity : Human

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Acetyl-Ref-1 (Lys6) Polyclonal Antibody


Background information : The role of transcription factors in the regulation of gene expression is well established. Although the activity of these factors can be regulated by phosphorylation,evidence has indicated regulation of DNA binding mediated by changes in reduction-oxidation (redox) status. Mutational analysis has identified a single conserved cysteine residue mapping within the DNA binding domains of Fos and Jun. Chemical oxidation or modification of this cysteine residue inhibits the DNA binding activity of Fos and Jun. A similar mode of regulation has been recently proposed for other nuclear transcription factors. Oxidation is reversible by these compounds or by a cellular redox/DNA repair protein identified originally as Ref-1 (redox factor 1). Ref-1 is identical to a previously characterized DNA repair enzyme designated HAP1, APE or APEX.


Research area(s) : Epigenetics | Neuroscience


Validated applications : WB | ELISA


Suggested dilutions : WB 1:500-1:2000, ELISA 1:5000-1:20000


Calculated MW : 36 kDa


Observed MW (if applicable)  : 35 kDa


Alternate names: APEX1, APE, APE1, APEX, APX, HAP1, REF1, DNA-(apurinic or apyrimidinic site) lyase, APEX nuclease, APEN, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1, REF-1, Redox factor-1


Available sizes : 20 ul, 60 ul, 120 ul, 200 ul


Conjugation : none


Clonality : Rabbit polyclonal


Isotype : IgG


Clone number :


Reactivity : Human


Immunogen : Synthesized peptide derived from the human Ref-1 around the acetylation site of K6.


Swissprot ID : P27695


Gene ID / Accession : 328 /


Purification method : Affinity purification


Supplied in : PBS with 0.02% sodium azide, 50% Glycerol and 0.5% BSA


Concentration : 1 mg/ml


Storage : Store at -20°C. Avoid freeze / thaw cycles.


Other informations :

Link to Elabscience product page

Previous Catalog Number: ENK022


Manual & Datasheet


Additional information

Validated Applications

WB, ELISA

Reactivity

Human

Research Area(s)

,

Product Name

Acetyl-Ref-1 (Lys6) Polyclonal Antibody

Supplier

Isotype

IgG

Host

Rabbit

Clonality

Polyclonal

Format

20 ul, 60 ul, 120 ul, 200 ul

Conjugation

None

Antibody Name

Acetyl-Ref-1 (Lys6) Polyclonal Antibody

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