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Acetyl-Ref-1 (Lys6) Polyclonal Antibody – E-AB-20213

  • Clonality : Rabbit Polyclonal
  • Applications : WB | ELISA
  • Reactivity : Human

169.00$599.00$ CAD


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Acetyl-Ref-1 (Lys6) Polyclonal Antibody

Background information : The role of transcription factors in the regulation of gene expression is well established. Although the activity of these factors can be regulated by phosphorylation,evidence has indicated regulation of DNA binding mediated by changes in reduction-oxidation (redox) status. Mutational analysis has identified a single conserved cysteine residue mapping within the DNA binding domains of Fos and Jun. Chemical oxidation or modification of this cysteine residue inhibits the DNA binding activity of Fos and Jun. A similar mode of regulation has been recently proposed for other nuclear transcription factors. Oxidation is reversible by these compounds or by a cellular redox/DNA repair protein identified originally as Ref-1 (redox factor 1). Ref-1 is identical to a previously characterized DNA repair enzyme designated HAP1, APE or APEX.

Research area(s) : Epigenetics | Neuroscience

Validated applications : WB | ELISA

Suggested dilutions : WB 1:500-1:2000, ELISA 1:5000-1:20000

Calculated MW : 36 kDa

Observed MW (if applicable)  : 35 kDa

Alternate names: APEX1, APE, APE1, APEX, APX, HAP1, REF1, DNA-(apurinic or apyrimidinic site) lyase, APEX nuclease, APEN, Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1, REF-1, Redox factor-1

Available sizes : 20 ul, 60 ul, 120 ul, 200 ul

Conjugation : none

Clonality : Rabbit polyclonal

Isotype : IgG

Clone number :

Reactivity : Human

Immunogen : Synthesized peptide derived from the human Ref-1 around the acetylation site of K6.

Swissprot ID : P27695

Gene ID / Accession : 328 /

Purification method : Affinity purification

Supplied in : PBS with 0.02% sodium azide, 50% Glycerol and 0.5% BSA

Concentration : 1 mg/ml

Storage : Store at -20°C. Avoid freeze / thaw cycles.

Other informations :

Link to Elabscience product page

Previous Catalog Number: ENK022

Manual & Datasheet

Additional information

Validated Applications




Research Area(s)


Product Name

Acetyl-Ref-1 (Lys6) Polyclonal Antibody









20 ul, 60 ul, 120 ul, 200 ul



Antibody Name

Acetyl-Ref-1 (Lys6) Polyclonal Antibody

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